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Live vaccines usually work by giving you a shot of a small amount of virus in order for your immune system to fight it and be familiar with that virus.
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If you are under the treatment of Prednisone, please stay away from sick people or places wherein you could get infected because while you are under Prednisone, your immune system becomes weaker and may cause your current condition to worsen.
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Prednisone is a member of a group of drugs which is called corticosteroids.